|
Symbol Name ID |
Fasl
Fas ligand MGI:99255 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal lymphocyte apoptosis |
Decreased lymphocyte apoptosis |
Increased circulating IgA level |
Increased circulating IgE level |
Decreased circulating IgG level |
Increased circulating IgG level |
Decreased circulating total IgM |
Increased circulating IgM level |
Decreased specific anti-polysaccharide antibody level |
Increased circulating antibody level |
Reduced delayed hypersensitivity |
Autoimmune hemolytic anemia |
Eosinophilia |
Neutropenia in presence of anti-neutropil antibodies |
Increased B cell count |
Decreased proportion of CD4-positive helper T cells |
Abnormal proportion of CD4-positive T cells |
Abnormal proportion of CD8-positive T cells |
Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells |
Increased proportion of HLA DR+ T cells |
Lymphocytosis |
Lymphopenia |
Leukocytosis |
Abnormal granulocyte morphology |
Abnormal basophil morphology |
Ph-positive acute lymphoblastic leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Autoimmune thrombocytopenia |
Recurrent aphthous stomatitis |
Lymphadenopathy |
Chronic noninfectious lymphadenopathy |
Follicular hyperplasia |
Splenomegaly |
Hepatosplenomegaly |
Hypersplenism |
Colitis |
Helicobacter pylori infection |
Peritoneal abscess |
Hepatitis |
Thyroiditis |
Uveitis |
Glomerulonephritis |
Abnormal circulating interleukin concentration |
Increased circulating interleukin 10 concentration |
Increased circulating interleukin 18 concentration |
Panniculitis |
Autoimmunity |
Anti-smooth muscle antibody positivity |
Antineutrophil antibody positivity |
Antinuclear antibody positivity |
Antiphospholipid antibody positivity |
Platelet antibody positive |
Rheumatoid factor positive |
Systemic lupus erythematosus |
| Disease(s) Associated with FASLG | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| chronic myeloid leukemia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| pre-eclampsia |
| Mouse Phenotypes | immune system phenotype |
increased B cell proliferation |
abnormal T cell proliferation |
increased T cell proliferation |
impaired macrophage phagocytosis |
abnormal thymus cell ratio |
enlarged thymus |
enlarged spleen |
increased spleen weight |
abnormal T cell differentiation |
abnormal double-negative T cell morphology |
increased neutrophil cell number |
decreased granulocyte number |
increased germinal center B cell number |
increased plasma cell number |
decreased B cell number |
increased T cell number |
increased lymphocyte cell number |
increased leukocyte cell number |
abnormal T cell morphology |
increased IgA level |
increased IgE level |
increased IgG1 level |
increased IgG2a level |
increased IgG2b level |
decreased IgG level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal cytotoxic T cell physiology |
decreased cytotoxic T cell cytolysis |
abnormal osteoclast physiology |
increased circulating tumor necrosis factor level |
abnormal interleukin level |
abnormal lymph node morphology |
enlarged lymph nodes |
lymphoid hyperplasia |
abnormal humoral immune response |
impaired humoral immune response |
autoimmune response |
increased susceptibility to autoimmune diabetes |
increased susceptibility to systemic lupus erythematosus |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
CNS inflammation |
brain inflammation |
eye inflammation |
liver inflammation |
glomerulonephritis |
interstitial pneumonia |
dermatitis |
increased susceptibility to bacterial infection |
increased susceptibility to Picornaviridae infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Fasldel1Hong/Fasldel1Hong | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faslgld/Faslgld | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faslm1Btlr/Faslm1Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faslm2Btlr/Faslm2Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Fasltm1.1Ast/Fasltm1.1Ast | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Fasltm1.1Bksa/Fasltm1.1Bksa | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Fasltm1.1Cgm/Fasltm1.1Cgm | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Fasltm1.1Lest/Fasltm1.1Lest | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Fasltm2.1Ast/Fasltm2.1Ast | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(Ins2-Fasl)24Ach/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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